Brian Baker

Contact information

Lawrence Livermore National Laboratory
7000 East Avenue
Livermore, CA 94550
phone: 925 422 3247


Ph.D. - Physical Chemistry - University California, Los Angeles 2003
B.A. - Chemistry - Rice University, 1996


Brian's research applies bioanalytical chemistry, biophysical chemistry, and surface chemistry techniques towards the development of biosensors, biomaterials, and medical devices. Applications of interest include bioterrorism surveillance, point-of-care detection of pathogenic microorganisms, and other national security needs. 

Recent publications

Wheeler, E.K., Baker, B.R., Piggott, W.T., Mabery, S.L., Hara, C.A., DeOtte, J., Benett, W., Mukerjee, E.V., Dzenitis, J., and Beer, N.R. “On-Chip Laser-Induced DNA Dehybridization”. Analyst, 138(13): 3692 (2013).

Bearinger, J.P., Dugan, L.C., Baker, B.R., Hall, S.B., Ebert, K., Mioulet, V., and King, D.P. “Development and Initial Results of a Low Cost, Disposable, Point-of-Care Testing Device for Pathogen Detection”. IEEE Trans. Biomed. Eng., 58: 805 (2011).

Torres, C.L., Vitalis, E.A., Baker, B.R., Gardner, S.N., Torres, M.W., and Dzenitis, J.M. “LAVA: An Open-Source Approach To Designing LAMP (Loop-Mediated Isothermal Amplification) DNA Signatures”. BMC Bioinformatics, 12: 240 (2011).

Cho, H., Baker, B.R., Wachsmann-Hogiu, S., Pagba, C.V., Laurence, T.A., Lane, S.M., Lee, L.P., and Tok, J.B.-H. “Aptamer-based SERRS Sensor for Thrombin Detection”. Nano Lett., 8: 4386 (2008).

Hindson, B.J., Reid, S.M., Baker, B.R., Ebert, K., Ferris, N.P., Bentley Tammero, L.F., Lenhoff, R.J., Naraghi-Arani, P., Vitalis, E.A., Slezak, T.R., Hullinger, P.J., and King, D.P. “Diagnostic evaluation of a multiplexed RT-PCR microsphere array assay for the detection of foot-and-mouth and look-alike disease viruses”. J. Clin. Microbiol., 46: 1081 (2008).

Xiao, Y., Lubin, A.A., Baker, B.R., Plaxco, K.W., and Heeger, A.J. “Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex”. Proc. Natl. Acad. Sci. USA, 103: 16677 (2006).

Lubin, A.A., Lai, R.Y., Baker, B.R., Heeger, A.J., and Plaxco, K.W. “Sequence-specific, electronic detection of oligonucleotides in blood, soil and foodstuffs with the reagentless, reusable E-DNA sensor”. Anal. Chem., 78: 5671 (2006).

Baker, B.R., Lai, R.Y., Wood, M.S., Doctor, E.H., Heeger, A.J., and Plaxco, K.W. “An Electronic Aptamer-Based Small Molecule Sensor for the Rapid, Label-Free Detection of Cocaine in Adulterated Samples and Biological Fluids”. J. Am. Chem. Soc., 128: 3138 (2006).


Benner, W.H., Dzenitis, J.M., Benett, W.J., and Baker, B.R. “Fluidics Platform and Method for Sample Preparation and Analysis”. US Patent Application 13/228,391. Sep 8, 2011.

Riot, V.J., Dzenitis, J.M., Benett, W.J., Benner, W.H., Hadley, D.R., and Baker, B.R. “Fluidics Cartridge and Reaction Platform”. US Patent Application 13/228,384. Sep 8, 2011.

Cho, H., Baker, B.R., Lee, L.P., and Bearinger, J.P. “Microfluidic Platform and Related Methods and Systems”. US Patent Application 20100136551. Jun 3, 2010.

Cho, H., Lane, S.M., Baker, B.R., Wachsmann-Hogiu, S., Pagba, C.V., Tok, J.B.-H., Laurence, T.A., and Lee, L.P. “Aptamer Based Sensors and Related Methods and Systems”. US Patent Application 20100105053. Apr 29, 2010.